The REVA trial, published in the New England Journal of Medicine in 2022, addresses a critical question in the management of mechanically ventilated patients: Which strategy for spontaneous breathing trials (SBTs)—Pressure-Support Ventilation (PSV) or a T-piece—offers better outcomes? Objective of … Read More
Clinical Trials at your Fingertips!
Revolutionizing Medical Reference with Quick, Accessible Summaries of Landmark Clinical Trials - Right at Your Fingertips.
Latest Clinical Trials
CAMMS223 Trial: Alemtuzumab vs. Interferon B1a in Early Multiple Sclerosis
Published in the New England Journal of Medicine (2008), the CAMMS223 trial provides critical insights into the efficacy of Alemtuzumab compared to Interferon Beta-1a in patients with early, relapsing-remitting multiple sclerosis (RRMS). This phase 2, randomized, blinded study highlights the … Read More
ATTENTION Trial: Endovascular Treatment for Acute Basilar-Artery Occlusion
Published in the New England Journal of Medicine (2022), the ATTENTION Trial is a landmark study exploring the efficacy and safety of endovascular treatment (EVT) for patients with acute basilar artery occlusion (BAO). Here’s an in-depth look at the findings … Read More
ATHENA-HF Trial: High-Dose Spironolactone in Acute Heart Failure
The ATHENA-HF trial, published in JAMA Cardiology in 2017, evaluated the efficacy and safety of high-dose spironolactone in patients with acute heart failure (AHF). This was a double-blind, placebo-controlled randomized clinical trial, aiming to assess whether high-dose spironolactone could significantly … Read More
FAST Trial: Screening Frequency for SBT
The FAST Trial: Examining Screening Frequency and Spontaneous Breathing Trial Techniques in Critically Ill Adults In the realm of critical care, optimizing strategies to wean patients off invasive mechanical ventilation is a cornerstone of patient management. The recently published FAST … Read More
TRISCEND II Trial: Transcatheter Tricuspid Valve Replacement in Severe TR
TRISCEND II Trial: EVOQUE Transcatheter Tricuspid Valve Replacement (TTVR) Severe tricuspid regurgitation (TR) has historically been challenging to treat, with medical therapy offering limited relief. The TRISCEND II trial (2024) marks a significant milestone by assessing the safety and efficacy … Read More
MS-SMART Trial: Neuroprotection in Multiple Sclerosis
MS-SMART Trial: Evaluating Neuroprotection in Secondary Progressive Multiple Sclerosis Secondary progressive multiple sclerosis (SPMS) remains one of the most challenging forms of MS to treat, as no effective therapies currently exist to halt disease progression. The MS-SMART trial (2020) was … Read More
AMBER Trial: Patiromer to Allow Spironolactone use in Resistant Hypertension
Resistant hypertension poses a significant challenge, especially in patients with chronic kidney disease (CKD). The AMBER trial emerges as a beacon of hope, evaluating the role of the potassium binder patiromer in enabling the use of spironolactone in this difficult-to-treat … Read More
PROMPT-AF Trial: PVI With Optimized Linear Ablation for Persistent AFib
Understanding the PROMPT-AF Trial: A Breakthrough in Persistent AF Management The PROMPT-AF trial marks an important step forward in our understanding of how to manage persistent atrial fibrillation (AF) more effectively. Conducted as an investigator-initiated, multicenter, open-label randomized trial, PROMPT-AF … Read More